Benfotiamine 150 + Alpha-Lipoic Acid 300 - 60 vcaps

What is Doctor's Best Benfotiamine + Alpha-Lipoic Acid? Benfotiamine (S-benzoylthiamine-O-monophosphate) is a synthetic derivative of thiamin (vitamin B1). Benfotiamine is fat-soluble, more bioavailable, & physiologically active than thiamin. Benfotiamine helps maintain healthy cells in the presence of blood glucose, supports against oxidative stress, & supports healthy aging. Alpha-Lipoic Acid supports the body's defense against free radicals & recycles antioxidant nutrients such as vitamin C & vitamin E. Alpha-lipoic acid is a sulfur-containing fatty acid, it is soluble in both water & fat & is sometimes referred to as the "universal antioxidant". How it works? Benfotiamine raises the blood level of thiamin pyrophosphate, the biologically active coenzyme of thiamin, & stimulates transketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways. Benfotiamine was shown to cause, on average, a 5-fold greater increase in blood thiamin levels than thiamin mononitrate, with a concomitant greater thiamin concentration in red blood cells. Benfotiamine readily passes through intestinal cells & is converted into thiamin. Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose for energy production. Aging is accompanied by a decreased ability of the liver to recycle ascorbic acid following oxidative stress. R-lipoic acid, after two weeks of supplementation to aged rats, reversed the age-related impairment of ascorbic acid recycling & concentration in liver cells. Aging is associated with oxidative stress in the brain. The brain's high rate of metabolism & its long-lived neurons make it particularly vulnerable to oxidative stress. Since alpha-lipoic acid interrupts cellular oxidative processes in both its oxidized & reduced forms, it plays a modulatory role in the brain & nervous system.